Elkus Manfredi Architects

Elkus Manfredi Architects is a Boston-based architecture, interior design and planning firm founded in 1988 by Howard Elkus and David Manfredi. The practice works across life sciences and research, higher education, healthcare, commercial office, mixed-use districts and hospitality, and has shaped large pieces of the Boston Seaport, Kendall Square and Harvard’s Allston campus. Its life sciences portfolio is among the deeper ones in the country, which matters when a client needs lab planning and developer-grade cost discipline in the same drawing set. The firm designed the 600,000-square-foot, seven-story South Campus Research Building 5 at MD Anderson Cancer Center in Houston, a $668 million research facility completed in spring 2026 on the institution’s South Campus.